Lonesome George was the famed last representative of a giant tortoise species once found on the Galapagos island of Pinta. Image credit: Mark Putney

Lonesome George was the famed last representative of a giant tortoise species once found on the Galapagos island of Pinta. Image credit: Mark Putney

Famous giant tortoise DNA may hold fountain of youth: UCBO

After Lonesome George’s death he still provides clues to longer life

Ever since Darwin’s first steps on the Galapagos Islands, understanding the adaptations that offer the giant tortoise its extended lifespan has been a tantalizing scientific pursuit.

And now, new research by an international team including researchers from UBC’s Okanagan campus has used the DNA from one famous giant tortoise to uncover the genes that are associated with their longevity. The discovery provides clues to better understand aging in humans and may help preserve the species says Michael Russello, study co-author and biology professor at UBC Okanagan.

“Giant tortoises are among the longest living vertebrate animals and have become an interesting model for studying longevity and age related-disease,” said Russello. “Even though they’re one of few animals that can live longer than 100 years, there has been surprisingly little research into the giant tortoise genome.”

RELATED: UBCO and BCIT team up to brew cannabis-infused beverages

To help identify the genes that give the giant tortoise its extended lifespan, the researchers compared the complete DNA sequence from two long-lived giant tortoises. They used samples from Lonesome George—the famed last representative of a species once found on the Galapagos island of Pinta—and from another giant tortoise species found on the Aldabra atoll, a coral island in the Indian Ocean.

RELATED: UBCO sociology class calls on Kelowna Chiefs to change “derogatory” name

By comparing the giant tortoise genomes with those from other species, including humans, they found interesting variation within genes linked to DNA repair, immune response, and cancer suppression not possessed by shorter-lived vertebrates. None of those genomic variants had been previously associated with aging, offering new avenues for further study.

While individual tortoises have remarkable longevity, Russello says the Galapagos giant tortoises do not, with all living species considered threatened or endangered. He says the results of their study could provide clues into the biological processes and adaptations that gave rise to giant tortoises in the first place, while helping to better protect these animals on the verge of disappearing altogether.

“Lonesome George was a very interesting character in his own right, embodying the plight of endangered species until his death in 2012,” said Russello. “While he inspired many while he was alive, his legacy now lives on through a story written in his DNA.”

To report a typo, email:
newstips@kelownacapnews.com
.


@KelownaCapNews
newstips@kelownacapnews.com

Like us on Facebook and follow us on Twitter.

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

Community members Ed Hutchinson, left, Dave Noren, and Pat Graham, president of The Ladies Guild, stand before the new book house outside the Church of the Advent in Colwood. The tiny library was built as a result of the annual Church of the Advent book sale being cancelled due to COVID-19. (Submitted/Joan Hoffman)
Colwood church builds little library

Church of Advent annual book sale cancelled due to health restrictions

To each their own pipe. The new sewer main during staging in James Bay before it was installed in 2018, to convey waste to the McLoughlin Point treatment facility. (Black Press Media file photo)
‘End in sight,’ for Victoria’s annual sewage overflows

Wastewater projects underway should end sewage overflows

(Courtesy Very Good Butchers)
Very Good Butchers brand adds cheese to its platter

The Cultured Nut products to be rebranded under Very Good Cheese banner

Ron Sivorot, business director at Kennametal’s Langford site, the Greater Victoria facility that made a component being used on NASA’s Perseverance rover on Mars. (Jake Romphf, Black Press Media)
NASA’s Perseverance Mars rover using piece made at Kennametal’s Langford site

The Greater Victoria plant’s tooth blank is helping the rover’s drill collect rock cores

June Saxe, 2, enjoys the sunny shoreline at Whiffin Spit with her dad on March 5. The family had come out from Victoria for a day in the sunshine. (Nina Grossman/News Staff)
PHOTOS: Warm weather brings Sooke’s Whiffin Spit to life

Visitors, locals enjoy warm weather at coastal viewpoint

The James C Richardson Pipe Band marches in a Remembrance Day parade on Nov. 11, 2019 in Chilliwack. Wednesday, March 10 is International Bagpipe Day. (Jenna Hauck/ Chilliwack Progress file)
Unofficial holidays: Here’s what people are celebrating for the week of March 7 to 13

International Bagpipe Day, Wash Your Nose Day and Kidney Day are all coming up this week

Kevin Haughton is the founder/technologist of Courtenay-based Clearflo Solutions. Scott Stanfield photo
Islander aims Clearflo clean drinking water system at Canada’s remote communities

Entrepreneur $300,000 mobile system can produce 50,000 litres of water in a day, via solar energy

Malawian police guard AstraZeneca COVID-19 vaccines after the shipment arrived in Lilongwe, Malawi, Friday March 5, 2021. Canada is expecting its first shipments of AstraZeneca vaccine next week. (Associated Press/Thoko Chikondi)
B.C.’s daily COVID-19 cases climb to 634 Friday, four more deaths

Currently 255 people in hospital, 66 in intensive care

A crashed helicopter is seen near Mt. Gardner on Bowen Island on Friday March 5, 2021. Two people were taken to hospital in serious but stable condition after the crash. (Irene Paulus/contributed)
2 people in serious condition after helicopter goes down on Bowen Island

Unclear how many passengers aboard and unclear where the helicopter was going

Surrey Pretrial in Newton. (Photo: Tom Zytaruk)
B.C. transgender inmate to get human rights hearing after being held in mostly male jail

B.C. Human Rights Tribunal member Amber Prince on March 3 dismissed the pretrial’s application to have Makayla Sandve’s complaint dismissed

Supporters rally outside court as Pastor James Coates of GraceLife Church is in court to appeal bail conditions, after he was arrested for holding day services in violation of COVID-19 rules, in Edmonton, Alta., on Thursday March 4, 2021. THE CANADIAN PRESS/Jason Franson
‘Law remains valid:’ Pastor accused of violating health orders to remain in jail

The Justice Centre for Constitutional Freedoms is representing the pastor

The Netflix logo on an iPhone. B.C. delayed imposing sales tax on digital services and sweetened carbonated beverages as part of its response to COVID-19. Those taxes take effect April 1, 2021. THE CANADIAN PRESS/AP, Matt Rourke
B.C. applies 7% sales tax on streaming, vaping, sweet drinks April 1

Measures from 2020 budget were delayed due to COVID-19

A lawyer wears a face mask and gloves to curb the spread of COVID-19 while waiting to enter B.C. Supreme Court, in Vancouver, B.C., Friday, Aug. 28, 2020. British Columbia’s highest court has sided with the land owner in a dispute over public access to public land. THE CANADIAN PRESS/Darryl Dyck
B.C. high court finds in favour of large landowner in fight over access to pair of lakes

The Nicola Valley Fish and Game Club launched legal action after the cattle company blocked road and trail access

Prime Minister Justin Trudeau holds a press conference in Ottawa Friday, March 5, 2021. THE CANADIAN PRESS/Sean Kilpatrick
Trudeau holds firm on premiers’ health-care funding demands, COVID-19 aid comes first

Premiers argue that the current amount doesn’t keep pace with yearly cost increases of about five per cent

Most Read